A retrospective analysis of plasma exchange combined with glucocorticosteroids in the treatment of systemic lupus erythematosus associated with acute pancreatitis

• DOI: 10.3760/cma.j.issn.1007-7480.2015.06.013
• Publication Date: 2015-06-15
• Authors: Yikai Yu; Ju Li; Xiaowei Huang; Yecheng Feng; Linli Dong; Shaoxian Hu
• Keywords: Group B; Group A

Objective To investigate the clinical features and mechanism feasibility of plasma exchange (PE) in treating systemic lupus erythematosus (SLE) complicated with acute pancreatitis (AP).

Methods A retrospective analysis SLE associated AP was done based on HIS Tongji Hospital. Totally 24 SLEAP patients were admitted to hospital from March 2006 May 2014. Patients' serum amylase, lipase interleukin (IL)-6 concentration measured before after exchange. According different therapy strategy, divided into two groups. Fifteen treated combination glucocorticosteroid (GC) classified as Group A, other 9 who GC only group B. At baseline treatment, lipid concentration, average daily dosage between A B compared ANOVA IL-6 roup Wilcoxon rank test.

Results SLEDAI score at (16±5) no statistically that (18±4) (t=1.31, P= 0.320). Average 31.0(20.50, 30.08) mg/d significantly less than 47.85 (45.58, 59.23) (Z=35.50, 0.002). Serum levels not 13.14(11.12,16.57) mg/L vs 14.63(11.37, 16.37) (Z=12.20, P=0.300), 2 weeks level, which 9.16(7.93, 10.75) mg/L, decreased while it didn't show tendency decrease B, 13.62(9.29, 17.63) (Z=28.50, P=0.039). [TC=(5.02±0.53) mmol/L, TG=(1.46±0.44) mmol/L] [TC=(6.11±0.50) TG=(2.14±0.65) (F=4.46, P=0.010; F= 6.09, P=0.002), similar wasn't observed B(F=1.57, P>0.05).

Conclusion PE combined could lower levels, reduce amount improve prognosis. Therefore might be a safe effective way is worthy continuing explore its feasibility.

Key words: Lupus erythematosus, systemic; Pancreatitis, necrotizing; Plasma exchange; Glucocorticoids; Interleukin-6