Localized primary sclerosing cholangitis mimicking as a Klatskin tumour: report of three cases

• DOI: 10.3760/cma.j.issn.1007-8118.2014.01.012
• Publication Date: 2014-01-28
• Authors: Xiaolei Liu; Zhiying Yang; Haidong Tan; Yongliang Sun; Shuang Si; Li Xu; Liguo Liu
• Keywords: Klatskin tumor; Primary Sclerosing Cholangitis; Histopathology; Intrahepatic Cholangiocarcinoma

Objective To report three cases of localized primary sclerosing cholangitis (PSC) mimicking a hilar cholangiocarcinoma (Klatskin tumor) and to summarize their clinical characteristics the ways differentiate them through literature review.Method The data patients with PSC were retrospectively analyzed.The laboratory tests imaging examination reviewed,and therapy prognosis discussed.Results all diagnosed have preoperatively,but diagnosis was confirmed by histopathology post-operatively.All had elevated CA19-9,2 anti-nuclear antibody (ANA) 2 IgG.All underwent surgical resection histopathological study showed chronic inflammation bile ducts intrahepatic portal area.The followed up from 7 months 8 years no symptoms.Conclusions Localized is rare it can casily be misdiagnosed as cholangiocarcinoma.Biopsy before surgery helpful for differential but difficult get good biopsy sample.Surgical an effective treatment.

Key words: Cholangitis, sclerosing; Digestive system Procedures