Expressions and their Significance of Ki-67, p53, and survivin in esophageal cancer and precancerosis

• DOI: 10.3760/cma.j.issn.1008-1372.2015.02.019
• Publication Date: 2015-02-20
• Authors: Wenxin Xu; Junrong Yang; Qiushi Wang; Guangquan Xu
• Keywords: Survivin; Grading (engineering); Ki-67; Atypical Hyperplasia; Epithelial dysplasia; Clinical Significance

Objective To investigate the expressions and clinical significance of Ki-67, p53, survivin in esophageal cancer precancerosis.

Methods The proteins were detected by immunohistochemical staining 40 normal mucosa, 136 precancerosis (42 mild atypical hyperplasia, 43 moderate 51 severe hyperplasia), 68 tissues. The correlation three expressed carcinoma tissues was analyzed.

Results The positive expression rate Ki-67 0 (0/40)for epithelium, 35.7% (15/42) for dysplasia, 51.2% (22/43) 74.5% (38/51) 92.6% (63/68) squamous carcinoma, respectively. p53 protein (0/40) 28.6% (12/42) 46.5% (20/43) 52.9% (27/51) 67.6% (46/68) 38.1% (16/42) 55.8% (24/43) 64.7% (33/51) 89.7% (61/68) Rank analysis showed that abnormal correlated significantly with pathological grading lesions (r=0.637, 0.454, 0.590, P<0.01). positively (r=0.407, 0.646, P<0.01).

Conclusions The associated processes canceration, joint detection parameters has important value.

Key words: Esophageal neoplasms/ME; Esophageal diseases/ME; Ki-67 antigen/ME; Genes, p53; Microtubule-associated proteins/ME