Clinical efficacy of platinum-based chemotherapy combined radiotherapy for cervical cancer

• DOI: 10.3760/cma.j.issn.1008-6315.2012.06.006
• Publication Date: 2012-06-01
• Authors: Zhiyuan Xu; Lian-xing Lin; Mingming Yan
• Keywords: Nedaplatin; Chemoradiotherapy; Bone marrow suppression

Objective To evaluate the clinical efficacy of platinum-based chemotherapy combined radiotherapy for cervical cancer.Methods From October 2008 to June 2010,61 patients with cancer were treated by radiotherapy( conventional external radiation and after-loading brachytherapy,to a total dose 8000- 8500 cGy)combined (cisplatin or nedaplatin 20 mg/m2,one times per weeks) in our department.The side effects evaluated.Results Among 61 patients,the short-term effective rate was 100％ ( 61/61 ) 1-year survival 85.2％ 52/61 ).There no significant difference between cisplatin group 84.6％ vs.85.7％,x2 =0.014,P=0.095).Arrest bone marrow at Ⅰ,Ⅱ,Ⅲ Ⅳlevel occurred 5,24,5 1 group,and 6,12,3 3 group.There also these two groups great mass induced chemoradiotherapy (x2 =6.402,P =0.171 ).Conclusion It is worth practising carcinoma.The low.

Key words: Cervical neoplasms; Radiotherapy; Chemotherapy; Nedaplatin ; Cisplatin