Clinical value of combined detection of urinary microproteins in acute promyelocytic leukemia with arsenic trioxide in childhood

• DOI: 10.3760/cma.j.issn.1009-9921.2010.11.005
• Publication Date: 2010-11-25
• Authors: Liangchun Hao; Ji-shun Zhao; Xiuli Wang; Hong Wang; Huan Wang; Gang Xu
• Keywords: Arsenic Trioxide; Beta-2 microglobulin

Objective To study the renal toxicity of arsenic trioxide (As2O3) with therapeutic dose in acute promyelocytic leukemia (APL) childhood. Methods Renal 37 APL was monitored. The examinations urinary routine, microproteins[αt1-microglobulin (α1-MG), microalbumin (mAlb),β2-microglobulin (β2-MG), transferrin(TRF)] and function were performed. Results Five cases leukocyturia, three hematuria, six proteinuria observed before therapy. Ketonuria occurred associated fever less diet; overall abnormality disappeared first week. No significant changes blood uric nitrigen(BUN), serum creatinine(Cr) acid (UA) founded induction remission. Compared tests As2O3 infusion, obvious increase α1-MG second week trioxide, β2-MG third (P ＜0.01), slow recovery fifth mAlb TRF seen Conclusion gentle general dose, tubercular damage could be seen. important monitoring period to remission.Influence cumulant on not serious near future combined detection microproteins dynamic variety detect early As2O3.

Key words: Promyelocytic, leukemia, acute; Arsenicals; Kidney tests; Urinary microproteins; Childhood