The correlation between aspirin resistance and P2Y1 gene polymorphism in patients with cardiovascular or cerebrovascular diseases

• DOI: 10.3760/cma.j.issn.1671-0282.2013.08.017
• Publication Date: 2013-08-10
• Authors: Pei Ye; Yongxia Li; Minjie Zhou; Pingan He; Ge Rile; Dong-cheng Shi; Wei Shu-zhi

Objective To investigates a group of 2 candidate single nucleotide polymorphisms in P2Y1 gene the blood platelet aggregation pathway associated with aspirin resistance (AR).Methods A total 330 patients Emergency wards and Cardiovascular Department Shanghai Sixth People' s Hospital were enrolled from October 2010 to March 2012.All subjects examined including TC、TG、HDL-C、LDL-C,blood routine,fasting glucose (FBG).Following course treatment for at least 7 days,platelet stimulated by arachidonic acid (AA) adenosine diphosphate (ADP) was observed,and analyzed polymerase chain reaction DNA sequencing assay.Results Of patients,95 (28.79％) had AR,and 235 (71.21％) sensitive aspirin.Type diabetes (OR =2.773),hypertension =3.992),and low level HDL =6.087) independent risk factors development AR,This SNP comprise T C base substitution position 893 gene,and increase 3.16、95％ CI 1.36-7.16、P =0.04).Conclusions The type Ⅱ diabetescidence,hypertension AR.There is correlation between mutation (893C ＞ T) resistance.

Key words: Aspirin resistance; Gene sequencing; polymorphisms; Platelet