Analysis on risk factors of liver histological change in chronic hepatitis B patients with low alanine aminotransferase level

• DOI: 10.3760/cma.j.issn.1673-4149.2017.02.006
• Publication Date: 2017-04-25
• Authors: Jiajie Zhang; Haijun Huang; Yongxi Tong
• Keywords: Hepatitis B; Alanine aminotransferase; HBeAg; Liver function

Objective To investigate the risk factors of liver histological change in chronic hepatitis B patients with low ALT level.

Methods A total 321 level 2 times lower than upper limit normal (ULN) who accepted biopsy Zhejiang Provincial People's Hospital from January 2014 to September 2016 were enrolled, and divided into significant group (n=217) non-significant (n=104) . The clinical data including gender, age, WBC, function, HBeAg HBV DNA analyzed. Logistic regression was uesd screen multi-variables build forecasting model. ROC curve drawn based on prediction probability.

Results The medians ALT, AST γ-GT (35.14±9.35) years old, 29.00 U/L, 25.00 19.00U/L, which all obviously (t=-3.214, P<0.01; Z=-2.269, P<0.05; Z=-4.596, Z=-2.810, P<0.01) While PLT, ALB (197.09±64.44) ×109/L, 45.25 g/L, 5.16 lgIU/mL, higher (t=2.777, Z=3.148, Z=2.387, P<0.05) showed that (OR=1.071, 95% CI=1.043-1.100) (OR=0.828, CI=0.743-0.923) may be related change. AUROC probability 0.714 sensitivity specificity 63.13% 70.19%, respectively.

Conclusions AST are individual level.

Key words: Hepatitis B, chronic; Histology; Alanine aminotransferase