Glycemic control of adult patients with type 2 diabetes mellitus treated by oral antidiabetic drugs in combination with insulin in China in 2009

• DOI: 10.3760/cma.j.issn.1674-5809.2012.08.007
• Publication Date: 2012-08-27
• Authors: Xiaohui Guo; Linong Ji; Juming Lu; Wenying Yang; Jianping Weng; Weiping Jia; Dajin Zou; Zhiguang Zhou; De-min Yu; Jie Liu; Zhongyan Shan; Yuzhi Yang; Renming Hu; Dalong Zhu; Liyong Yang; Li Chen; Zhigang Zhao; Qifu Li; Haoming Tian; Qiuhe Ji; Jing Liu; Jiapu Ge; Lixin Shi
• Keywords: Glycated hemoglobin; Regimen

Objective To assess current treatment and glycaemic control of adult subjects with type 2 diabetes mellitus (T2DM) in China, focusing on the therapy oral anti-diabetic drugs (OAD) combination insulin.

Methods From July to September 2009, 400 hospitals from 75 cities across China were selected by Chinese Diabetes Society for this cross-sectional study. All T2DM patients (over 18 years) antidiabetic drug with/without insulin eligible General information patients, duration diabetes, medical history, complications concomitant diseases, glycated hemoglobin A1c(HbA1c), fasting blood glucose (FBG), postprandial (PBG) regimen recorded. data analyzed using SAS 9.13 software.

Results A total 143 123 enrolled study (73 544 males 69 579 females, median age 59 years, 6 years). Among treated plus OADs, most frequently used is pre-mix (65.5%, 34 487/52 649), followed basal (24.3%, 12 794/52 649) basal-bolus (8.5%, 4492/52 649). The percentage achieved HbA1c<6.5% was 20.2% (28 985/143 123) overall populations, 23.4% (21 163/90 474) 14.9% (7822/52 OADs only respectively. Within achieving 15.2% (1944/12 794), (5150/34 487) 14.6% (656/4492) group, pre-mixed group HbA1c target decreased increase (all P<0.05). Patients initiated earlier stage had more chance achieve P<0.01). Data also indicated that pressure lipid profile remained low China. In total, there 23.5% (33 676/143 reached 37.4% (53 550/143 123), 41.4% (59 320/143 19.2% (27 418/143 671/143 triglyceride(TG), cholesterol(TC), high-density lipoprotein cholesterol(HDL-C) low-density cholestorol(LDL-C) targets, respectively.

Conclusion The rate T2DM, which even lower those OADs. This indicates effective individualized needed patients.

Key words: Diabetes mellitus, 2; Oral drugs; Insulin; Glycemic