Layer-by-layer analysis of retinal thickness in primary open-angle glaucoma using optical coherence tomography

• DOI: 10.3760/cma.j.issn.1674-845x.2014.10.003
• Publication Date: 2014-10-25
• Authors: Meng Zhang; Chang Zhang; Yuhong Wang; Fan Lyu
• Keywords: Ganglion cell layer; Inner plexiform layer; Inner nuclear layer

Objective To analysis each layer of retinal thickness,especially the ganglion cell (GCL) in macular area,in patients with primary open-angle glaucoma (POAG) using an RTVue OCT; to assess its value diagnosis glaucoma.Methods In this prospective case-control study,76 (91 eyes) POAG (30 [30 eyes] early stage,25 [29 middle stage and 21 [32 late stage) 32 healthy age-and gender-matched controls (32 were recruited.The area was scanned OCT,and retina divided into nine layers self-programming image processing software.The thickness total calculated LSD-t test used compare average for early,middle control group.Results POAG,the mean thicknesses nerve fiber (RNFL) 31.6±9.2 μm 33.9±5.0 μm,respectively,becoming thinner (P＜0.05) than controls.In stage,the RNFL GCL 31.2±3.4 34.1±3.9 μm,respectively,which group (P＜0.05).In RNFL,GCL,inner plexiform (IPL),inner segment photoreceptor (IS),and (TR) 18.8±7.6 μm,24.2±7.9 μm,38.0±6.4 μm,22.8±4.4 299.5±15.1 μm,respectively,and all measurements (P＜0.05).The inner nuclear (INL) 39.1±6.6 μm,which thicker (P＜0.05).Conclusion The became obviously thinner.The especially affected by POAG.GCL combined clinical observations can be as diagnostic indicator POAG.

Key words: Glaucoma,open-angle ; Tomography,optical coherence Retinal