Protective effects of neuroglobin in arsenic-induced nervous system injury

• DOI: 10.3760/cma.j.issn.2095-4255.2017.04.018
• Publication Date: 2017-04-20
• Authors: Tingting Liu; Jing Wang
• Keywords: Neuroglobin

Neuroglobin (Ngb) is a globin with high affinity to oxygen and specifically expressed in the brain of vertebrates. Many studies show that Ngb's expressions change it may have protective effects nervous system injury, such as ischemia/hypoxia. Mechanisms role include free radicals scavenging, anti-oxidative stress, well anti-apoptosis. Ngb can also play transduction signal increase downstream phosphatidylinositol-3-kinase/protein serine threonine kinase (PI3K/AKT) activities. Arsenic exposure lead oxidative stress apoptosis, injury. In this article, we summarized expression changes neuroglobin injuries, out looked endemic arsenic poisoning induced injury.

Key words: Neuroglobin; Arsenic; Nervous