Glycosystems in nanotechnology: Gold glyconanoparticles as carrier for anti-HIV prodrugs

• DOI: 10.3762/bjoc.10.136
• Publication Date: 2014-06-12T11:58:40Z
• Authors: Fabrizio Chiodo; Marco Marradi; Javier Calvo; Eloisa Yuste; Soledad Penadés
• Keywords: Abacavir

The therapeutic approach for the treatment of HIV infection is based on highly active antiretroviral therapy (HAART), a cocktail drugs. Notwithstanding HAART has shown different drawbacks like toxic side effects and emergence viral multidrug resistance. Nanotechnology offers new tools to improve drug prevention. In this scenario, gold nanoparticles are an interesting chemical tool design prepare smart efficient drug-delivery systems. Here we describe preparation antiviral activity carbohydrate-coated loaded with anti-HIV prodrug candidates. nucleoside reverse transcriptase inhibitors abacavir lamivudine have been converted corresponding thiol-ending ester derivatives then conjugated ~3 nm glucose-coated by means “thiol-for-thiol” ligand place exchange reactions. drugs-containing glyconanoparticles were characterized pH-mediated release from nanoparticle determined. was tested evaluating replication NL4-3 in TZM-bl infected cells. proof-of-principle presented work aims introduce as multifunctional system against HIV.