Sordarin, an antifungal agent with a unique mode of action

• DOI: 10.3762/bjoc.4.31
• Publication Date: 2008-09-05T10:18:39Z
• Authors: Huan Liang
• Keywords: Mode of Action

The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including norbornene system, inhibits protein synthesis in fungi stabilizing the ribosome/EF2 complex. This mode action is contrast to typical antifungals, which target cell membrane. unusual bioactivity makes promising candidate for development new fungicidal agents, and provided motivation extensive research. Three total syntheses (by Kato, Mander Narasaka groups), modifications glycosyl unit, changes (Cuevas Ciufolini models) will also be discussed this review.