A Shift in SARS-CoV-2 Omicron Variant’s Entry Pathway Might Explain Different Clinical Outcomes

• DOI: 10.37757/mr2022.v24.n3-4.10
• Publication Date: 2022-10-31T19:53:40Z
• Authors: Calixto Machado-C...; Joel Gutierrez-Gil; Alina González-Qu...
• Keywords: Pathogenesis; Pandemic

Globally, SARS CoV-2 omicron variant has led to a notable increase of COVID-19 diagnoses, although with less severe clinical manifestations and decreased hospitalizations. The wave swelled faster than previous waves, completely displacing the delta within weeks, creating worldwide concern about final, successful pandemic control. Some authors contend that symptoms associated differ from 'traditional' more closely resemble those common cold. One major symptom frequent other variants-loss taste smell-is rarely present omicron. This may be interest, since it also been suggested direct SARS-CoV-2 invasion into brainstem through olfactory nerves by transsynaptic pathways could provide one explanation for acute respiratory distress syndrome refractory treatment. Brainstem infection can severely damage center, triggering functional deviations affect involuntary respiration, leading treatment, main cause death in patients. A shift entry pathway cell-surface fusion, triggered TMPRSS2, cathepsin-dependent fusion endosome, transmission, cellular tropism pathogenesis. Therefore, we hypothesize this entrance modification impact transmission nerve pathways. decrement virus's diminish center dysfunction, reducing need mechanical ventilation.