[Recent Progress of Nano-drug Combined with Chimeric Antigen Receptor T Cell Therapy in the Treatment of Soild Tumors].

• DOI: 10.3779/j.issn.1009-3419.2023.102.02
• Publication Date: 2023-01-20
• Authors: Yi Liu; Ning Li; Wenyang Jiang; Qing Geng

Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable success in treating hematological malignancies. However, CAR-T for solid tumors is still limited due to the unique solid-tumor microenvironment and heterogeneous target expression, which leads an urgent need of combining other therapies. At present, nano delivery system become one most promising directions development anti-tumor drugs. Based on background tumor treatment, we focus research progress nanomedicine combined with therapy, systematically review strategies examples recent years aspects vivo mRNA, regulation microenvironment, combination photothermal therapy. And also look forward future direction this filed. .【中文题目：纳米药物联合CAR-T疗法在实体肿瘤治疗中 的研究进展】 【中文摘要：嵌合抗原受体T细胞（chimeric cell, CAR-T）疗法在血液系统肿瘤治疗中已取得巨大成功，但由于实体肿瘤特殊的肿瘤微环境和缺乏特异性的抗原靶点，CAR-T疗法在实体肿瘤中的治疗效果并不理想，联合其他疗法是目前的迫切需要。当前，纳米递送系统已经成为抗肿瘤药物研发最活跃的方向之一，本文在介绍CAR-T疗法与实体肿瘤治疗相关的背景基础上，重点关注纳米药物联合CAR-T疗法以增强肿瘤治疗的研究进展，从体内递送mRNA、调节肿瘤微环境、联合光热治疗等方面，较为系统地综述了近年来纳米递送系统联合CAR-T疗法的策略与典例，同时对该领域的未来方向进行展望。 】 【中文关键词：纳米递送系统；嵌合抗原受体T细胞疗法；实体肿瘤】.