Relevancy of blood specimen-molecular biomarkers in studying osteoporosis in postmenopausal women

• DOI: 10.37897/rmj.2025.1.5
• Publication Date: 2025-02-24T12:25:01Z
• Authors: Bassam Dawood; Naael H. Ali; ; Shereen Al-Ali
• Keywords: Postmenopausal osteoporosis

Background. Osteoporosis is a bone disease characterized by low mass and micro-architectural weakening of tissue. It can be influenced, in part, immunological activity. Therapeutically targeting immune factors that promote osteoporosis could protect larger number susceptible individuals, especially postmenopausal women, from this debilitating disease. The aim the present study to evaluate blood levels gene expression for RANKL, RANK, OPG, OSCAR, transcription RORᵧt FOXP3 (as representatives Th17 Treg cells, respectively) determine their potential as biomarkers detecting osteoporosis. Methods. A total 88 women were included study: 43 with (PO group), 45 without (PNO group) age-matched controls, 40 young healthy females baseline controls (YA group). Blood samples collected all participants assess interest using qRT-PCR. Results. There was non-significant increase RANKL PO group compared PNO YA groups (PO=1.68, PNO=1.53, YA=1.0). population significantly elevated (PO=1.53, No statistical differences observed among other genes. Conclusion. prominent osteoclastogenic marker detected blood. Although crucial factor resorption, its level appears inconclusive.