Treatment of difficult-to-treat-dermatophytosis: results of a randomized, double-blind, placebo-controlled study

• DOI: 10.3855/jidc.14666
• Publication Date: 2021-12-10T21:57:00Z
• Authors: Sanjeewani Fonseka; Dilan Dileepa Jay...; Dasun Chathumina ...; Narankotuwe Gedar...; Pallegoda Vithana...
• Keywords: Griseofulvin; Placebo-controlled study

Introduction: Difficult-to-treat dermatophytosis is an emerging public health problem in Sri Lanka. Safe, effective and affordable treatment needed to solve this problem. Therefore study has assessed the effectiveness safety of modified Whitfield ointment applied twice daily with oral griseofulvin 500 mg given over 8 weeks patients difficult-to-treat dermatophytosis.
 Methodology: A randomized, double-blind, within-patient-placebo-controlled trial was conducted clinico- mycologically (history, physical examination, direct light microscopy examination scales potassium hydroxide mount) confirmed dermatophytosis. Lesions were randomized receive (5% benzoic acid 5% salicylic acid) or emulsifying ointment. All 500mg once daily. The outcome measures clinical assessment disease severity, total surface area lesions patient’s perception severity at baseline every two up a maximum weeks.
 Results: Thirty completed study. At weeks, there statistically significant improvement arm patients' perception. There 7.59% reduction 5.83% increase weeks. difference between arms changes not (p = 0.107, df 29).
 Conclusions: combination significantly effective, safe option for treating tropics.