Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway

• DOI: 10.3892/ijmm.2022.5190
• Publication Date: 2022-09-14T10:19:01Z
• Authors: Weichao Sun; Wei Xie; Dixi Huang; Yinxing Cui; Jiaji Yue; Qifei He; Luoyong Jiang; Jianyi Xiong; Wei Sun; Qian Yi
• Keywords: MMP3

Osteoarthritis (OA) is the most common degenerative disease affecting joints, and inflammation appears to play a critical role in initiation progression of OA. Caffeic acid phenethyl ester (CAPE), natural flavonoid compound, has anti‑inflammatory antioxidant functions. However, its effects on OA underlying mechanisms action CAPE treatment remain elusive. Therefore, present study investigated IL‑1β‑stimulated chondrocytes vitro surgically induced rat models vivo. In vitro, reduced expression inducible nitric oxide synthase cyclooxygenase‑2 chondrocytes, as well extracellular secretion prostaglandin E2 cell culture supernatants. addition, attenuated degradation matrix by increasing aggrecan collagen II, decreasing MMP3, MMP13 disintegrin metalloproteinase with thrombospondin motif‑5. Furthermore, NF‑κB signaling activated nuclear factor erythroid 2‑related 2/heme oxygenase‑1 pathway chondrocytes. vivo, protected cartilage from destruction delayed rats. Taken together, findings indicated that may be potential therapeutic agent for prevention or