Cell kinetic patterns in early gastric cancer.

• DOI: 10.3892/ijo.12.4.883
• Publication Date: 2014-03-10T03:24:02Z
• Authors: D Spina; C Miracco; C Vindigni; M Gallorini; L Presenti; D Marrelli; F Roviello; E Pinto; M I Filipe; P Tosi
• Keywords: 0301 basic medicine; lymph node metastasis; Mitosis; Apoptosis; Cell Count; early gastric cancer; mitotic index; apoptotic index; cell density; lymph node metastasis; 3. Good health; 03 medical and health sciences; Stomach Neoplasms; apoptotic index; Proliferating Cell Nuclear Antigen; Humans; early gastric cancer; mitotic index; cell density

Early gastric cancers (EGC) may be subdivided into 2 groups by means of the use of mitotic index, apoptotic index and cell density: EGCs with high cell turnover and low cell density, which show high cell dissociation and, more frequently, lymph node invasion; EGCs with low cell turnover and high cell density. The same parameters discriminate among intestinal type tumors, when separately considered from diffuse ones. No correlation is noted of these 2 groups with transforming growth factor-alpha, epidermal growth factor receptor and p53 expression, gross type, entity of neoangiogenesis, and submucosal invasion.