Clinicopathologic significance of protein induced vitamin K absence or antagonist II and alpha-fetoprotein in hepatocellular carcinoma.

• DOI: 10.3892/ijo.14.2.281
• Publication Date: 2014-03-10T07:25:00Z
• Authors: T Nakagawa; T Seki; T Shiro; M Wakabayashi; M Imamura; T Itoh; T Tamai; A Nishimura; N Yamashiki; K Matsuzaki; N Sakaida; K Inoue; A Okamura
• Keywords: HCCS; Concomitant; Glypican 3; Alpha-fetoprotein

Protein induced vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) have been considered useful serum markers of hepatocellular carcinoma (HCC). In this study, we examined the clinicopathologic significance these tumour in patients with HCCs by measuring their levels performing immunohistochemistry. We studied 349 Japanese HCCs. Their PIVKA-II AFP were determined enzyme immunoassay before treatment. correlations between size, presence satellite nodules, histologic HCC grade, concomitant liver diseases subjected tissues to immunohistochemical staining detect expression. The poorly differentiated significantly higher than those well moderately (p<0.05) they without nodules. influenced diseases, but not other factors. Immunohistochemical revealed expression (p<0.05). Some cells PIVKA-II-positive, others AFP-positive, some expressed both. concentration was a better indicator AFP, as it diseases. correlated nodules result concordant findings.