BUTYRATE-INDUCED DIFFERENTIATION IN LEUKEMIC MYELOID CELLS - IN-VITRO AND IN-VIVO STUDIES

• DOI: 10.3892/ijo.4.6.1387
• Publication Date: 2014-03-10T03:20:59Z
• Authors: A REPHAELI; J NORDENBERG; A AVIRAM; E RABIZADEH; Y ZIMRA; A NUDELMAN; A NOVOGRODSKY; M SHAKLAI
• Keywords: Sodium butyrate; Differentiation Therapy; Tretinoin

A study of the effects three differentiating agents, butyric acid, retinoic acid and cytosine arabinoside on proliferation differentiation primary cultures, obtained from sixteen patients with myelo-proliferative disorder was conducted. The results showed that BA an effective inhibitor cell inducer cytodifferentiation. An acute non-lymphoblastic leukemia patient treated sodium butyrate. temporary increase in differentiation-associated parameters were noted. However, SB short-lived. lack clinical response led to development a prodrug pivaloyloxymethylbutyrate (AN-9). This more potent vitro than induction cytodifferentiation inhibition proliferation.