Apolipoprotein E genetic polymorphism, serum lipoprotein levels and breast cancer risk: A case-control study

• DOI: 10.3892/mco.2014.369
• Publication Date: 2014-08-01T07:47:57Z
• Authors: GABRIELA HERRMANN...; JULIANA GIACOMAZZI; ERNESTINA AGUIAR; SILVANA SCHNEIDER; BETINA ETTRICH; CAROLINE ISOPPO D...; SUZI CAMEY; MAIRA CALEFFI; BERNARDETE WEBER; PATRICIA ASHTON-P...; EMILIO HIDEYUKI M...
• Keywords: Apolipoprotein E

The purpose of this study was to evaluate the association between apolipoprotein E (APOE) allelic frequency, serum lipoproteins and breast cancer (BC). We conducted a nested case-control within cohort including 47 cases 165 controls. Polymerase chain reaction-restriction fragment length polymorphism analyses APOE were performed. In general, participants with genotype alleles e2 e3 tended have lower triglycerides, total cholesterol low‑density lipoprotein levels higher high‑density (HDL) compared homozygous for allele heterozygous e4 alleles, respectively. BC patients exhibited mean (p=0.070), dietary fat intake (p=0.020) (p=0.017) control subjects. distribution two groups revealed that presence positively associated absence BC, whereas case group (p=0.019). genotypes not significantly different controls (p=0.172). concomitant e4/e4 homozygosity (p=0.021). Our findings suggested plays an important role in development particularly when triglyceride levels.