Upregulation of circulating cytokeratin 20, urokinase plasminogen activator and C-reactive protein is associated with poor prognosis in gastric cancer

• DOI: 10.3892/mco.2015.624
• Publication Date: 2015-08-18T09:32:56Z
• Authors: ZHONGZHU TANG; HUAYING SHENG; XIAO ZHENG; LISHA YING; LIE WU; DONG LIU; GUAN LIU
• Keywords: Plasminogen activator inhibitor-1

Gastric cancer is one of the most common types cancer, with a high mortality rate. The aim this study was to investigate role several key molecules, including cytokeratin (CK) 19 and CK20, urokinase plasminogen activator (uPA), C-reactive protein (CRP) matrix metalloproteinase (MMP)-9, which are involved in invasion metastasis, order determine whether they may be considered as novel prognostic factors for gastric cancer. Peripheral blood collected from 165 patients adenocarcinoma who underwent curative surgical resection at Zhejiang Cancer Hospital (Hangzhou, China) between 2010 2011. mRNA levels CK19, uPA MMP-9 were detected by reverse transcription-quantitative polymerase chain reaction. expression CRP measured immunoturbidimetry. Student's t-test used univariate analyses Kaplan‑Meier method analyze survival curves. relative CK19 not found significantly associated gender, age or stage, whereas that CK20 stage: low‑expression group early‑stage high‑expression more advanced‑stage disease (p<0.05). level gender predominantly male disease, female CRP, but MMP-9, negatively overall (OS): OS rate groups lower compared In conclusion, upregulation negative factor