Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound‑guided needle biopsy specimens of prostate adenocarcinoma

• DOI: 10.3892/mco.2021.2353
• Publication Date: 2021-07-16T06:49:45Z
• Authors: Jagtar Singh; Thanuja Thachil; Mathew Eapen; Aijye Lim; Wajiha Sufyan; Robert Rawson; Henry Duncan; Paolo De Ieso; Sukhwinder Sohal
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Cytokines influence the biological behaviour of prostate cancer (PC) and may patient outcome serve as useful prognostic biomarkers. The aim present study was to evaluate cytokine expression levels in prostatic needle biopsy specimens association with clinicopathological characteristics patients PC. A total 18 PC who underwent transrectal ultrasound (TRUS) guided were included clinical study. These naïve radiotherapy (RT) or androgen deprivation therapy prior TRUS follow up data collected. Cytokine analysed by using immunohistochemistry Spearman's correlation test used determine between characteristics. Expression pro‑inflammatory TNF‑α IL‑6 decreased Gleason score (GS) increased; however, a statistically significant difference not detected. statically observed specimen pre‑RT plasma sample (P=0.01 P=0.05, respectively) anti‑inflammatory TGF‑β1 (P=0.05). However, further studies are needed confirm these results larger size value