Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma

• DOI: 10.3892/mmr.2016.5418
• Publication Date: 2016-06-21T11:32:43Z
• Authors: Ji-Zong Lin; Li-Li Meng; Yan-Zhu Li; Shu-Xian Chen; Jian-Liang Xu; Ya-Jun Tang; Nan Lin
• Keywords: Hepatic stellate cell; Angiopoietin; Pathogenesis

Previous studies have determined that activated hepatic stellate cells (aHSCs) promote the progression of hepatocellular carcinoma (HCC) by increasing angiogenesis in cancerous tissues. In addition, angiopoietin 1 (Ang‑1) has been reported to be involved tumor growth and metastasis via promotion angiogenesis. It remains unclear whether aHSCs Ang‑1 are HCC. A total 25 HCC tumor‑adjacent tissues, 21 normal liver tissues were used present study. Immunohistochemistry (IHC) was detect expression α smooth muscle actin (α‑SMA). The CD34 also analyzed using IHC evaluate microvessel density (MVD). protein levels evaluated western blot analysis. association between aHSC, Spearman's rank correlation coefficient. study α‑SMA, MVD (CD34) significantly higher when compared with analysis identified a positive CD34. This suggests α‑SMA‑positive promoted expressing Ang‑1, resulting proliferation