Statin rosuvastatin inhibits apoptosis of human coronary artery endothelial cells through upregulation of the JAK2/STAT3 signaling pathway

• DOI: 10.3892/mmr.2020.11266
• Publication Date: 2020-06-23T06:17:22Z
• Authors: Kuijing Wang; Bo Li; Yuanyuan Xie; Nan Xia; Minghui Li; Guang Gao
• Keywords: Janus kinase 2

The purpose of the present study was to explore potential molecular signaling pathway mediated by statin rosuvastatin in cultured human coronary artery endothelial cells (HCAECs) induced CoCl2. CoCl2 used induce apoptosis HCAECs. Myocardial infarction rats were established and received or PBS treatment. Reverse transcription‑quantitative PCR, western blotting, ELISA, TUNEL assay immunohistochemistry analyze role results showed that treatment decreased HCAECs increasing anti‑apoptosis Bcl‑xl Bcl‑2 expression, decreasing pro‑apoptosis Bax, Bad, caspase‑3 caspase‑9 expression. myocardial ischemia rat model demonstrated mitochondrial reactive oxygen species, inflammation, damage, lipid catabolism, heart failure areas, but improved cardiac function indicators, right left ventricular ejection fraction increased expression levels Janus kinase (JAK) signal transducer activator transcription (STAT)3 tissue. In conclusion, current revealed presents cardioprotective effects activation JAK2/STAT3 pathway.