Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells

• DOI: 10.3892/or.2013.2635
• Publication Date: 2013-07-24T19:03:53Z
• Authors: HYUNG TAE LEE; MI RAN CHOI; MI SOOK DOH; KYOUNG HWA JUNG; YOUNG GYU CHAI
• Keywords: Tranylcypromine; Pargyline

Chemotherapy is one of the therapeutic strategies that has been used for inhibition cancer cell proliferation in several types cancer, including prostate cancer. Although monoamine oxidase (MAO) inhibitors, phytoestrogen and antioxidants chemotherapy have systematically studied, their effects on growth remain to be fully understood. The purpose this study was investigate MAO pargyline tranylcypromine survival human carcinoma (LNCaP-LN3) cells. After treating LNCaP-LN3 cells with or tranylcypromine, we examined proliferation, cycle pattern, apoptosis expression levels apoptosis-related genes. exposed decreased a dose- time-dependent manner, while tranylcypromine-treated showed opposite results. Treatment significantly induced arrest at G1 phase compared control In addition, an increase death rate by promoting apoptosis; however, had no effect Based our results, suggest more powerful than treatment