CD38 is highly expressed and affects the PI3K/Akt signaling pathway in cervical cancer

• DOI: 10.3892/or.2014.3537
• Publication Date: 2014-10-10T10:06:11Z
• Authors: SHAN LIAO; SONGSHU XIAO; GUANGCHAO ZHU; DANWEI ZHENG; JUNYU HE; ZHEN PEI; GUIYUAN LI; YANHONG ZHOU
• Keywords: Adult; Membrane Glycoproteins; Uterine Cervical Neoplasms; Proto-Oncogene Proteins c-mdm2; Middle Aged; ADP-ribosyl Cyclase 1; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; 0302 clinical medicine; Cell Line, Tumor; Humans; Female; Phosphatidylinositol 3-Kinase; Tumor Suppressor Protein p53; Proto-Oncogene Proteins c-akt; Cell Proliferation; Signal Transduction

Cervical cancer is the second most common cancer and the fifth most deadly malignancy in females worldwide, affecting 500,000 individuals each year. It is the leading cause of cancer mortality among women in developing countries. Dysregulated activation of genes, such as CD44, SOX9 and SKP2, plays a role in cervical cancer. CD38 is known to be involved in activities typical of cell surface receptors, such as signaling for activation and proliferation events and heterotypic cell adhesion. CD38 contributes to disease progression and relapse in certain tumors, such as acute myeloid and chronic lymphocytic leukemia. To the best of our knowledge, there is currently no report on the relationship between CD38 and cervical cancer. Using qPCR, immunohistochemistry, and western blot analysis, the expression levels of CD38 were investigated and found to be upregulated in cervical cancer. CD38 was correlated with dysregulation of the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway in cervical cancer tissues in vitro. At the same time, CD38 overexpression affected the expression of PI3K, Akt, MDM2 and p53 in vivo. The results of the present study suggested that CD38 is highly expressed in cervical carcinoma tissues and play an important role in dysregulation of the PI3K/Akt signaling pathway.