miR‑328‑3p enhances the radiosensitivity of osteosarcoma and regulates apoptosis and cell viability via H2AX

• DOI: 10.3892/or.2017.6112
• Publication Date: 2017-11-27T04:26:46Z
• Authors: Zhen Yang; Qing-De Wa; Chao Lu; Wei Pan; Zi-Μo Lu; Jun Ao
• Keywords: Radiosensitivity; Radioresistance

Osteosarcoma is a kind of high-risk sarcoma the skeleton typically observed in people under 25 years old. Currently, radiotherapy widely applied cancer treatment. However, osteosarcoma radioresistant and accordingly new, more effective radiosensitizers are needed. miRNAs have been reported to play an important role radiosensitivity. We examined modulating effect miR‑328‑3p vivo vitro. was downregulated HOS‑2R cells. The overexpression enhanced radiosensitivity inhibited proliferation promoted apoptosis cells radiation conditions. In overexpressing miR‑328‑3p, H2AX expression downregulated. found that targets inhibits its expression. It concluded, enhances radiosensitization following X-ray irradiation, determined it directly regulate radiosensitization.