Expression of Transforming Growth Factor beta - 1 in Chronic Hepatitis and Hepatocellular Carcinoma Associated with Hepatitis C Virus Infection

• DOI: 10.3904/kjim.2000.15.3.165
• Publication Date: 2015-07-30T07:01:54Z
• Authors: Hyung Gun Kim; Young Hwa Chung; Byung Cheol Song; Jeong A Kim; Soo Hyun Yang; Yung Sang Lee; Dong Jin Suh
• Keywords: Hepatitis virus

Background Transforming growth factor beta-1 (TGFβ 1) has been suggested to play a role in the development, or progression of hepatocellular carcinoma (HCC). Genotype and serum titer HCV also affect occurrence HCC chronic hepatitis C. In this study, we were evaluate effects genotype on expression TGFβ 1. We intended examine correlation between up-regulation 1 association with patients Methods studied 19 C 18 associated infection. was determined by line probe reverse hybridization assay amount HCV-RNA quantitated branched DNA signal amplification assay. Serum level measured enzyme linked immunosorbent Results genotypes similar those without it. higher 1b than non-1b (p<0.05). levels However, there no significant difference non-1b. Also, it not correlated alanine aminotransferase levels. Conclusion seems be overexpressed compared that C; affected ALT levels, titer. It is may malignant transformation hepatocyte HCV-associated HCC.