Kinetic and perfusion modeling of hyperpolarized (13)C pyruvate and urea in cancer with arbitrary RF flip angles.

• DOI: 10.3978/j.issn.2223-4292.2014.02.02
• Publication Date: 2014-02-01
• Authors: Naeim Bahrami; Christine Leon Sw...; Cornelius von Morze; Daniel B. Vigneron; Peder E. Z. Larson
• Keywords: Urologic Diseases; Liver Cancer; Biomedical Engineering; 610; Bioengineering; Optical Physics; Atomic; perfusion; Engineering; Rare Diseases; cancer; molecular and optical physics; Cancer; metabolic imaging; Prostate Cancer; Liver Disease; Molecular and Optical Physics; kinetic modeling; Condensed Matter Physics; Hyperpolarized carbon-13; Other Physical Sciences; dynamic MRSI; Physical Sciences; Biomedical Imaging; 4.4 Population screening; Digestive Diseases; Biomedical engineering

The accurate detection and characterization of cancerous tissue is still a major problem for the clinical management individual cancer patients monitoring their response to therapy. MRI with hyperpolarized agents promising technique because it can non-invasively provide local assessment metabolic profile. In this work, we measured kinetics [1-(13)C] pyruvate (13)C-urea in prostate liver tumor models using compressed sensing dynamic MRSI method. A kinetic model fitting method was developed that incorporated arbitrary RF flip angle excitation lactate conversion rate, Kpl, 0.050 0.052 (1/s) tumors, respectively, which significantly higher than Kpl healthy tissues [Kpl =0.028 (1/s), P<0.001]. highly correlated total signal ratio (correlation coefficient =0.95). We additionally characterized urea perfusion, as there both existing vasculature neovascularization different kinds lesions surpass normal blood supply, including small circulation disturbance some abnormal vessels. perfusion (accounting alanine) relative seen (liver cancer) compared (P<0.001), presumably due high uptake tumors.