Dehydrogenation of 5,6-Dihydropyrido[3,2-d]pyrimidin-7(8H)-ones: A Convenient Last Step for a Synthesis of Pyrido[2,3-d]pyrimidin-7(8H)-ones

• DOI: 10.3987/com-10-s(e)28
• Publication Date: 2010-11-24T00:32:09Z
• Authors: José I. Borrell; Irene Pérez-Pi; Xavier Berzosa; Iñaki Galve; Jordi Teixidó
• Keywords: 01 natural sciences; 0104 chemical sciences

Two new protocols for the dehydrogenation of 5,6-dihydropyrido[2,3-d]pyrimidin-7(8H)-ones to pyrido[2,3-d]pyrimidin-7(8H)--ones are described.The first one uses NaH in DMSO an affords corresponding pyridopyrimidines when aryl substituent is present at C6.The second a more general use, allowing and alkyl substituted 5,6-dihydropyridopyrimdines upon treatment with Na 2 SeO 3 DMSO.