Clinical and Genetic Features of Brainstem Glioma in Adults: A Report of 50 Cases in a Single Center

• DOI: 10.3988/jcn.2021.17.2.220
• Publication Date: 2021-04-08T05:56:18Z
• Authors: Chunhui Zhou; Hao Zhao; Fan Yang; Luokai Huangfu; Chao Dong; Shuwei Wang; Jianning Zhang
• Keywords: Single Center; Center (category theory)

Background and purpose Brainstem gliomas (BSGs) in adults are rare brain tumors with dismal outcomes. The aim of this study was to determine the clinical genetic features a series BSGs their association prognosis. Methods Fifty patients who underwent stereotactic biopsy between January 2016 April 2018 at single institution were collected. Data on clinicopathological characteristics analyzed factors associated patient survival identified using Cox regression model. Results median age diagnosis 55.5 years, 62% male. Glioblastoma (44%) accounted for largest proportion BSGs, oligodendroglioma (2 50) rarely encountered. IDH mutation (6 44) occurred infrequently astrocytomas, IDH-mutant harbored both ATRX loss MGMT promoter methylation relatively low level. Wild-type astrocytomas as having high rates 1p/19q codeletion (5 38) heterozygosity 1p (8 or 19q only. In diffuse midline glioma H3K27M mutant, three four cases. Patients offered radiotherapy and/or concurrent/adjuvant temozolomide chemotherapy, time 13 months. Multivariate analysis revealed that tumor grade, absence enhancement, duration symptoms ≥3 months, Karnofsky performance status ≥70, conferred advantage. Conclusions Adult showed different molecular characteristics, but also resembled supratentorial oncological