Preparation, Characterization and Evaluation <i>In Vitro</i> of Naringenin-PVP K-30 Solid Dispersions

• DOI: 10.4028/www.scientific.net/amr.236-238.2422
• Publication Date: 2011-05-17T15:54:22Z
• Authors: Shao Jin Zhong; Guang Fa Wang; Chun Lan Dai; Zheng Gen Liao; Nan Zhang; Chun Liu Wang; Xi Zhen Han
• Keywords: Vacuum drying

Solid dispersions (SD) were prepared with naringenin and polyvinyl pyrrolidone k-30 (PVP k-30) by the solvent evaporation method three drying methods (microwave-vacuum drying, MVD; spray SPD; vacuum VD). The physical state was characterized DSC, PXRD, SEM, FT-IR. results showed that vitro dissolution rate extent of improved significantly SD as compared pure drug mixtures (PM). FT-IR is possibly interacted PVP via intermolecular hydrogen bond, DSC PXRD all completely amorphous. Compared other methods, MVD can save time energy. stored in 40 °C/75% RH chamber stable month. These suggest feasible to replace traditional time-consuming low efficiency procedure for preparation SD.