Frailty-Independent Undertreatment Negative Impact on Survival in Older Patients With Breast Cancer

• DOI: 10.4048/jbc.2021.24.e45
• Publication Date: 2021-10-26T01:55:40Z
• Authors: Fernando Osório; António S. Barros; Bárbara Peleteiro; Ana Rita Barradas; Joana Urbano; José Luís Fougo; Adelino Leite-Mor...
• Keywords: Geriatric oncology

The management of older adults with breast cancer (BC) remains controversial. challenging assessment aging idiosyncrasies and the scarce evidence therapeutic guidelines can lead to undertreatment. Our goal was measure undertreatment assess its impact on survival.Consecutive patients BC aged 70 years or were prospectively enrolled in 2014. Three frailty screening tools (G8, fTRST, GFI) two functional status scales (Karnofsky performance score Eastern Cooperative Oncology Group Performance Status) applied. Disease characteristics, treatment options, causes mortality recorded during a 5-year follow-up. In addition, we defined correlated survival frailty.A total 92 included study. median age 77 (range 70-94) years. prevalence discordant 41.9%; 74.2%; GFI, 32.3%). Only 47.8% had local disease, probably due late diagnosis (73.9% based self-examination). Thirty-three (35.6%) died, which 15 from BC. We found considerably high proportion (53.3%) undertreatment, frailty-independent negative (hazard ratio [HR], 5.1; 95% confidence interval [CI], 2.1-12.5). Additionally, omission surgery overall (HR, 3.9; CI, 1.9-7.9).BC should be individualized. More importantly, assessing (not treat) is essential aware risk-benefit profile patient's well-informed willingness treated. Undertreatment daily practice frequent might have survival, as report.