Cutting Edge: JAM-C Controls Homeostatic Chemokine Secretion in Lymph Node Fibroblastic Reticular Cells Expressing Thrombomodulin

• DOI: 10.4049/jimmunol.1003441
• Publication Date: 2011-06-18T04:18:20Z
• Authors: Vincent Frontera; Marie-Laure Arcan...; Claudia Zimmerli; Florence Bardin; Elodie Obrados; Stéphane Audebert; Marc Bajenoff; Jean-Paul Borg; Michel Aurrand-Lions
• Keywords: Thrombomodulin; Reticular connective tissue; Reticular cell

Abstract The development and maintenance of secondary lymphoid organs, such as lymph nodes, occur in a highly coordinated manner involving chemokine production by stromal cells. Although developmental pathways inducing during organogenesis are known, signals maintaining cytokine adults still elusive. In this study, we show that thrombomodulin platelet-derived growth factor receptor α identify population fibroblastic reticular cells which secretion is controlled JAM-C. We demonstrate Jam-C–deficient mice treated with Ab against JAM-C present significant decreases cell-derived 1α (CXCL12), CCL21, CCL19 intranodal content. This effect correlated reduced naive T cell egress from nodes anti–JAM-C–treated mice.