Evidence for the Existence of Two Functionally Distinct Types of Cells Which Regulate the Antibody Response to Type III Pneumococcal Polysaccharide

• DOI: 10.4049/jimmunol.105.6.1581
• Publication Date: 2022-12-30T20:15:53Z
• Authors: Phillip J Baker; Philip W Stashak; Diana F Amsbaugh; Benjamin Prescott; Rolf F Barth
• Keywords: Antibody response; Reversion; Cell type; SSS*

Summary The administration of various types syngeneic lymphoid cells to mice immunized with type III pneumococcal polysaccharide (SSS-III) and treated anti-lymphocyte serum (ALS) revealed that at least two functionally distinct presumably thymic-derived (a suppressor cell an amplifier cell) act in opposing manner regulate the antibody response SSS-III. ability ALS increase magnitude SSS-III is apparently result inactivation a normally suppresses produced following immunization