Tick-Borne Encephalitis (TBE) and Hepatitis B Nonresponders Feature Different Immunologic Mechanisms in Response to TBE and Influenza Vaccination with Involvement of Regulatory T and B Cells and IL-10

• DOI: 10.4049/jimmunol.1300293
• Publication Date: 2013-07-20T04:36:47Z
• Authors: Erika Garner-Spitzer; Angelika Wagner; Maria Paulke-Korinek; Herwig Kollaritsch; Franz X Heinz; Monika Redlberger...; Karin Stiasny; Gottfried F Fischer; Michael Kundi; Ursula Wiedermann
• Keywords: Tick-borne encephalitis; Hepatitis B; Humoral immunity

Low responsiveness/nonresponsiveness is characterized by an insufficient immune response upon primary and/or booster vaccination and affects 1-10% of vaccinees. In the current study, we aimed to investigate whether nonresponsiveness Ag/vaccine-specific phenomenon clarify underlying immunological mechanisms. Nonresponders tick-borne encephalitis (TBE) or hepatitis B Ag with a history previous TBE vaccinations were vaccinated influenza vaccine compared high responders in terms humoral cellular response. Postboosters responder existing titers increased, solid responses induced. nonresponders, low undetectable prevaccination remained low, whereas sufficient Abs both groups, positive correlation was seen as high/low associated sufficient/lack Ag-specific T cell proliferation. Furthermore, robust cytokine production. contrast, Ags induced despite lacking specific IL-2 IFN-γ Importantly, these patients showed IL-10 baseline levels vitro. HLA-DR subtypes overrepresented this group, linked subtypes. Whereas nonresponders had increased IL-10-producing FOXP3(+) regulatory cells vaccination, only showing elevated levels, prominent population detected. We conclude that pathways follow different patterns depending on genetic predisposition vaccinee.