Involvement of the multilineage CD38 molecule in a unique pathway of cell activation and proliferation.

• DOI: 10.4049/jimmunol.145.8.2390
• Publication Date: 2022-12-31T07:58:36Z
• Authors: A Funaro; G C Spagnoli; C M Ausiello; M Alessio; S Roggero; D Delia; M Zaccolo; F Malavasi
• Keywords: Antigens, Differentiation, T-Lymphocyte; 0301 basic medicine; HLA-D Antigens; Membrane Glycoproteins; CD3 Complex; Plasma Cells; CD2 Antigens; Receptors, Antigen, T-Cell; Antibodies, Monoclonal; In Vitro Techniques; Flow Cytometry; Lymphocyte Activation; ADP-ribosyl Cyclase 1; Antigens, Differentiation; Cell Line; Killer Cells, Natural; 03 medical and health sciences; Antigens, CD; Humans; Receptors, Immunologic; ADP-ribosyl Cyclase; Cell Division

We report clear evidence that the interaction of CD38 molecule with specific mAb A10 on normal human cells and lines modulates expression surface activation markers relevant to T, NK, plasma cell biology functions. Moreover binding is followed by proliferation effects all target analyzed, phenomenon accessory IL-2 dependent. The synergizing both CD2 CD3 pathways indicate signal transduction mechanism(s) are apparently different from aforementioned. Nevertheless decreased A10-driven after CD3-Ti modulation suggests a possible functional interdependence between these pathways. Taken together, results might play physiologic role in regulation.