The role of monocyte chemotactic protein-1 (MCP-1) in the recruitment of monocytes and CD4+ T cells during a pulmonary Cryptococcus neoformans infection.

• DOI: 10.4049/jimmunol.155.10.4790
• Publication Date: 2022-12-31T11:32:59Z
• Authors: G B Huffnagle; R M Strieter; T J Standiford; R A McDonald; M D Burdick; S L Kunkel; G B Toews
• Keywords: Monocyte

Abstract Cryptococcus neoformans is acquired via the respiratory tract and leading cause of fatal mycosis in AIDS. Development a T cell-mediated pulmonary inflammatory response critical for clearance this pathogen; however, chemotactic factors that mediate cell recruitment into lungs have not been identified. In present study, bronchoalveolar lavage (BAL) fluid levels C-C chemokine monocyte protein-1 (MCP-1) cells both increased following infection with C. neoformans. The kinetics MCP-1 production correlated most closely CD4+ monocytes/macrophages. Administration neutralizing anti-MCP-1 Abs vivo reduced BAL MCP-1, decreased macrophages (> 95%) (76 +/- 9%), inhibited cryptococcal clearance. Although no vitro neutrophil or B activity has reported these leukocytes was also anti-MCP-1-treated mice (most likely an indirect effect reducing number macrophages). Neutralization resulted TNF-alpha IL-6. This first demonstration role infection, provides direct evidence plays cell-dependent immune to