Induction of antigen-specific T and B cell immunity in colon carcinoma patients by anti-idiotypic antibody.

• DOI: 10.4049/jimmunol.155.6.3253
• Publication Date: 2023-01-02T21:41:54Z
• Authors: R Somasundaram; J Zaloudik; L Jacob; A Benden; M Sperlagh; E Hart; G Marks; M Kane; M Mastrangelo; D Herlyn
• Keywords: Idiotopes; Polyclonal antibodies

Abstract Polyclonal goat anti-idiotypic Abs directed against anti-human gastrointestinal carcinoma mAb GA733 were administered to 13 colon cancer patients who had their primary tumor and lymph node metastases removed before immunotherapy. Patients received four s.c. doses (0.5 8 mg each) of alum-precipitated Ab. Seven the produced anti-anti-Ids that bound specifically epitope on cells shared idiotopes with GA733. In seven responding patients, anti-Id therapy modulated T cell responses. two did not demonstrate Ag/anti-Id-reactive therapy, administration induced CD4+, MHC class II-dependent proliferated in culture response stimulation either or Ag. other transiently lymphocytes suppressed proliferative responses cultured pretherapy Nine treated showed no evidence disease after 39 86 mo observation. Five these developed Ag-specific Ab3 one had, addition, a response.