Complement Deficiency Ameliorates Collagen-Induced Arthritis in Mice

• DOI: 10.4049/jimmunol.169.1.454
• Publication Date: 2014-04-21T00:33:01Z
• Authors: Max Albert Hietala; Ing-Marie Jonsson; Andrej Tarkowski; Sandra Kleinau; Marcela Pekna
• Keywords: Heterologous; Type II collagen; Collagen-induced arthritis

Abstract Collagen-induced arthritis (CIA) is an experimental animal model of human rheumatoid being characterized by synovitis and progressive destruction cartilage bone. CIA induced injection heterologous or homologous collagen type II in a susceptible murine strain. DBA/1J mice deficient complement factors C3 (C3−/−) factor B (FB−/−) were generated to elucidate the role system CIA. When immunized with bovine emulsified CFA, control developed severe high CII-specific IgG Ab titers. In contrast, C3−/− FB−/− highly resistant displayed decreased response. A repeated exposure 3 wk after initial immunization led increase response all triggered also complement-deficient mice. Although arthritic score was low, ranked intermediate regard We conclude that activation both classical alternative pathway plays deleterious