Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a Memory Immune Response

• DOI: 10.4049/jimmunol.169.3.1277
• Publication Date: 2014-04-22T04:06:27Z
• Authors: Anja E Hauser; Gudrun F Debes; Sergio Arce; Giuliana Cassese; Alf Hamann; Andreas Radbruch; Rudolf A Manz
• Keywords: CXCL9; CXCR3; CXCL16

Abstract Plasma blasts formed during memory immune responses emigrate from the spleen to migrate into bone marrow and chronically inflamed tissues where they differentiate long-lived plasma cells. In this study, we analyze chemokine responsiveness of after secondary immunization with OVA. Starting day 4 within ∼48 h, OVA-specific appear in marrow. Although these migratory cells have lost their many B cell attracting chemokines, e.g., CXC ligand (CXCL)13 (B lymphocyte chemoattractant), toward CXCL12 (stromal cell-derived factor 1α), inflammatory chemokines CXCL9 (monokine induced by IFN-γ), CXCL10 (IFN-γ-inducible protein 10), CXCL11 (IFN-inducible T α chemoattractant). However, is restricted a few days emigration spleen, indicating role for molecules cognate receptors, i.e., CXCR3 CXCR4, regulation blast migration and/or tissues.