Signaling Through NK Cell-Associated CD137 Promotes Both Helper Function for CD8+ Cytolytic T Cells and Responsiveness to IL-2 But Not Cytolytic Activity

• DOI: 10.4049/jimmunol.169.8.4230
• Publication Date: 2014-04-21T00:03:53Z
• Authors: Ryan A. Wilcox; Koji Tamada; Scott E. Strome; Lieping Chen
• Keywords: CD137; CTL*

Abstract NK cells possess both effector and regulatory activities that may be important during the antitumor immune response. In fact, generation of immunity by administration an agonistic mAb against CD137 is cell-dependent. this study, we report could induced IL-2 IL-15 to express ligation CD137-stimulated cell proliferation IFN-γ secretion, but not their cytolytic activity. Importantly, promoted expansion activated T in vitro, demonstrating immunoregulatory or “helper” activity for CD8+CTL. Furthermore, tumor-specific CTL P815 tumor Ags was abrogated following anti-CD137 treatment NK-depleted mice. We further demonstrate helper expressed high-affinity IL-2R were hyperresponsive IL-2. Taken together with previous findings a critical receptor costimulation cells, our suggest stimulatory involved crosstalk between innate adaptive immunity.