IFN-γ Polymorphisms (IFN-γ +2109 and IFN-γ +3810) Are Associated with Severe Hepatic Fibrosis in Human Hepatic Schistosomiasis (Schistosoma mansoni)

• DOI: 10.4049/jimmunol.171.10.5596
• Publication Date: 2014-04-20T22:22:42Z
• Authors: Christophe Chevil...; Carole Eboumbou M...; Nasr-Eldin M. A. ...; Jay H. Bream; Bourema Kouriba; Laurent Argiro; Siddig Rahoud; Adil Mergani; Sandrine Henri; Jean Gaudart; Qurashi Mohamed-Ali; Howard A. Young; Alain J. Dessein
• Keywords: Schistosoma

Abstract Schistosome infection is a major public health concern affecting millions of people living in tropical regions Africa, Asia, and South America. Schistosomes cause mild clinical symptoms most subjects, whereas small proportion individuals presents severe disease (as periportal fibrosis (PPF)) that may lead to death. Severe PPF results from an abnormal deposition extracellular matrix proteins the spaces due chronic inflammation triggered by eggs schistosome Ags. Extracellular protein production regulated number cytokines, including IFN-γ. We have now screened putative polymorphic sites within this gene population endemic area for Schistosoma mansoni. Two polymorphisms located third intron IFN-γ are associated with PPF. The +2109 A/G polymorphism higher risk developing PPF, +3810 G/A less result changes nuclear interactions intronic gene, suggesting they modify mRNA expression. These consistent previous studies. Indeed, controlled locus on chromosome 6q22-q23, closely linked encoding α-chain receptor, low producers been shown increased Together, these observations support view expression subsequent signal transduction play critical role control human hepatic (S. mansoni).