Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5− Phenotype

• DOI: 10.4049/jimmunol.178.12.7525
• Publication Date: 2014-04-18T23:18:11Z
• Authors: Wakiro Sato; Toshimasa Aranami; Takashi Yamamura
• Keywords: CCR2; CC chemokine receptors

Abstract Recent reports have shown that IL-17-producing CD4+ T cells (Th17 cells) belong to a distinct helper cell lineage and are critically involved in the pathogenesis of autoimmune diseases allergies. However, chemokine receptor profile Th17 remains be clarified. In this study, we report human identified as CCR2+CCR5− memory cells. Analysis PBMC from healthy donors showed CCR2+ produce much larger amounts IL-17 than CCR2− cells, indicating preferential expression CCR2 on Notably, produced large amount little IFN-γ, whereas CCR2+CCR5+ reciprocally an enormous IFN-γ but IL-17. Moreover, higher T-bet was seen CCR5+ These results indicate absence CCR5 distinguishes Th1