CD8+ tissue resident memory T cells are associated with good prognosis in breast cancer patients

• DOI: 10.4049/jimmunol.198.supp.196.11
• Publication Date: 2023-01-01T10:50:13Z
• Authors: Colt Egelston; Gayathri Srinivasan; Christian Avalos; Yinghui Huang; Anthony Rosario; Roger Wang; Grecia Jimenez; Diana L Simons; Susan Yost; Yuan Yuan; Peter P Lee
• Keywords: Tumor-infiltrating lymphocytes

Abstract CD8+ Tumor Infiltrating Lymphocytes (TILs) have been shown to correlate with patient prognosis in breast cancer. Recently, resident memory T cells (TRM) established as a potent functional subset of that exist peripheral tissue without recirculation. We assayed from fresh tumors phenotype and found them be almost exclusively made up effector cells. Further profiling by examining expression CD103 CD69 showed on average 40% TILs are composed TRM. Functional analysis these robust production IFNγ TNFα TRMs suggesting despite existence the tumor microenvironment maintain potency. To examine if TRM prognostic value cancer patients, we examined set primary ‘good’ ‘bad’ outcome which defined having relapse more than 5 years after diagnosis or less 3 respectively. In good patients represented 60% islands, while only 20% such bad patients. Similarly, were observed higher numbers both islands stroma comparison tumors. This significance was greater for general, highlighting importance affecting outcome. Finally also non-cancerous within mammary ducts associated epithelial perhaps surveillance potential pathogens. suggest vaccine target preventing recurrence metastasis