Specialized Proresolving Mediators Overcome Immune Suppression Induced by Exposure to Secondhand Smoke

• DOI: 10.4049/jimmunol.2000711
• Publication Date: 2020-10-28T19:35:10Z
• Authors: Tariq A Bhat; Suresh Gopi Kalathil; Austin Miller; Thomas H Thatcher; Patricia J Sime; Yasmin Thanavala
• Keywords: Proinflammatory cytokine

Abstract Tobacco smoke exposure is associated with multiple diseases including, respiratory like asthma and chronic obstructive pulmonary disease. a potent inflammatory trigger immunosuppressive, contributing to increased susceptibility infections in smokers, ex-smokers, vulnerable populations exposed secondhand smoke. also reduces vaccine efficacy. Therefore, mitigating the immunosuppressive effects of improving efficacy vaccinations individuals tobacco smoke, critical unmet clinical problem. We hypothesized that specialized proresolving mediators (SPMs), class immune regulators promoting resolution inflammation, without being enhancing B cell Ab responses, could reverse resulting from exposure. mice for 8 wk, followed by period cessation, were immunized P6 lipoprotein nontypeable Haemophilus influenzae, using 17-HDHA aspirin-triggered–resolvin D1 (AT-RvD1) as adjuvants. AT-RvD1 used adjuvants resulted elevated serum bronchoalveolar lavage levels anti-P6–specific IgG IgA protective, exhibiting more rapid bacterial clearance upon challenge, reduced infiltrates, production proinflammatory cytokines, less lung-epithelial damage. Furthermore, treatment during smoke-cessation further enhanced SPM-adjuvanted vaccination. Overall, SPMs show promise novel ability overcome smoke-induced effects.