Indeterminate cell histiocytosis with naïve cells

• DOI: 10.4081/rt.2013.e13
• Publication Date: 2013-05-03T09:20:13Z
• Authors: Ola A. Bakry; Rehab M. Samaka; Mona A. Kandil; Sheren F. Younes
• Keywords: Birbeck granules; Langerhans Cell Histiocytosis; CD68; Langerin; Juvenile xanthogranuloma; Histogenesis

Histiocytoses are a heterogeneous group of disorders characterized by proliferation and accumulation cells mononuclear-macrophage system dendritic cells. categorized according to the cell origin into Langerhans histiocytosis (LCH), Non histiocytoses indeterminate (ICH). ICH is an extraordinary rare neoplastic disorder that has poorly understood histogenesis pathogenesis. It cells, which mimic immunophenotypically (positive for CD1a S-100 protein), but lack Birbeck granules characteristic Twenty-four year-old Egyptian male was presented with reddish brown chest wall nodule. Clinical, histopathological, immunohistochemical ultrastructure features typical ICH. He in good state without any evidence recurrence or metastasis after 24 months follow up. Peculiar histopathological were detected present case. Many unidentified Hematoxylin & Eosin like showed negative staining S-100, CD1a, Langerin CD68. In absence cellular atypia mitosis, infiltrating epidermotropism reported once as well neural perineural invasion not previously reported. Therefore we prefer using tentatively designated diagnosis; tumor, otherwise specified newly proposed diagnosis (Indeterminate histocytosis naïve cells)