The Phospholipid Linoleoylglycerophosphocholine as a Biomarker of Directly Measured Insulin Resistance

• DOI: 10.4093/dmj.2017.41.6.466
• Publication Date: 2017-12-22T00:49:57Z
• Authors: Maria Camila Pére...; Martha Catalina M...; Freddy Jean Karlo...; Maria Laura Ricar...; Jose Oscar Mantil...; Jairo Arturo Pinz...; Maritza Perez-May...; Elizabeth Jiménez; Edwin Guevara; Carlos O Mendivil
• Keywords: Quartile; Glucose clamp technique

Background Plasma concentrations of some lysophospholipids correlate with metabolic alterations in humans, but their potential as biomarkers insulin resistance (IR) is insufficiently known. We aimed to explore the association between plasma linoleoylglycerophosphocholine (LGPC) and objective measures IR adults different profiles. Methods studied 62 men women, ages 30 69 years, (29% normal weight, 59% overweight, 12% obese). Participants underwent a 5-point oral glucose tolerance test (5p-OGTT) from which we calculated multiple indices secretion. Fifteen participants additionally hyperinsulinemic-euglycemic clamp for estimation insulin-stimulated disposal. LGPC was determined using high performance liquid chromatography/time-of-flight mass spectrometry. compared across quartiles defined by indices. Results Mean 15.4±7.6 ng/mL women 14.1±7.3 men. did not body in-dex, percent fat, waist circumference, blood pressure, glycosylated hemoglobin, log-triglycerides, or density lipoprotein cholesterol. systematically associated any 5p-OGTT-derived However, exhibited significant negative correlation disposal (Spearman r=−0.56, P=0.029). Despite being diabetic, higher significantly post-challenge excursions 5p-OGTT (P trend=0.021 increase area under curve LGPC). Conclusion In our sample Latino without known diabetes, showed biomarker impaired metabolism. Keywords: Adiposity; Biomarkers; Insulin resistance; Lipids; Obesity; Phospholipid