Renal outcome in biopsy proven cases of graft pyelonephritis

• DOI: 10.4103/0971-4065.132009
• Publication Date: 2014-05-06T07:35:45Z
• Authors: A Jairam; PP Varma; AK Hooda; S Badwal
• Keywords: Concomitant; Single Center

The incidence, risk factors and outcome of graft pyelonephritis are variably described in literature. All patients who had been transplanted at our center between January 2002 November 2006 presented with acute dysfunction were subjected to biopsy. Those neutrophilic casts interstitial inflammation predominant neutrophils included the study. Out 265 patients, 110 period underwent biopsy for dysfunction. 26 proven (AGPN). Nine early AGPN (within 6 months) other 17 late AGPN. Nearly 19% culture negative five no clinical features urinary tract infection; being a surprise finding on Among factors, only hepatitis C virus infection was significantly associated received 4-6 weeks antibiotics least 3 parenteral antibiotics. Majority (75%) experienced relapse Graft function lower months after onset when compared baseline, portending poor these patients. 26, 7 (27%) concomitant cellular rejection. treatment rejection, however, did not improve outcome.